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This product is the dried bark of Phellodendron chinenseSchneid., a plant of the Rutaceae family. It is commonly known as "Sichuan Huangbai". After peeling the bark, remove the rough skin and dry it in the sun.
This product is in the form of plates or shallow grooves, with different lengths and widths, and a thickness of 1~6mm. The outer surface is yellow-brown or yellow-brown, flat or with longitudinal grooves, and some have visible lenticel marks and residual gray-brown rough skin; the inner surface is dark yellow or light brown, with fine longitudinal ridges. It is light, hard, fibrous in cross section, flaky and layered, and dark yellow. It has a slight odor and tastes very bitter. It is sticky when chewed.
(1) The powder of this product is bright yellow. The fibers are bright yellow, 16~38μn in diameter, often in bundles, and the surrounding cells contain calcium oxalate crystals to form crystal fibers; the walls of the crystal-containing cells are lignified and thickened. The stone cells are bright yellow, round or spindle-shaped, 35~128μm in diameter, and some are branched, with sharp branch ends, thick walls, and obvious stratification; some have large fibrous stone cells, up to 900μm in length. There are many calcium oxalate crystals.
⑵Take 0.2g of the powder of this product, add 40ml of 1% acetic acid methanol solution, ultrasonically treat at 60℃ for 20 minutes, filter, and concentrate the filtrate to 2ml as the test solution. Take another 0.1g of Phellodendron chinense reference medicinal material, add 20ml of 1% acetic acid methanol, and prepare the reference medicinal material solution in the same way. Take the hydrochloric acid Phellodendron chinense reference substance, add methanol to prepare a solution containing 0.5mg per 1ml, as the reference substance solution. According to the thin layer chromatography method (General Rule 0502), take 3~5μ1 of each of the above three solutions, and spot them on the same silica gel G thin layer plate, use the lower layer solution of chloroform-methanol-water (30:15:4) as the developing agent, place it in a developing cylinder saturated with ammonia vapor, develop, take out, dry, and spray with dilute potassium iodide test solution. In the chromatogram of the test product, spots of the same color appear at the corresponding positions of the chromatogram of the reference medicinal material and the chromatogram of the reference substance.
Water content shall not exceed 12.0% (General Rule 0832, second method).
Total ash content shall not exceed 8.0% (General Rule 2302).
Determine by cold leaching method under the alcohol-soluble extract determination method (General Rule 2201), using dilute ethanol as solvent, and shall not be less than 14.0%.
Determine by high performance liquid chromatography (General Rule 0512).
Chromatographic conditions and system suitability test: Octadecylsilane bonded silica gel is used as filler; ethyl acetate-0.1% phosphoric acid solution (50:50) (0.1 g sodium dodecyl sulfonate is added per 100 ml) is used as mobile phase; detection wavelength is 265 nmo, and the number of theoretical plates calculated based on the hydrochloric acid hydrochloric acid peak should not be less than 4000. Preparation of reference solution: Take an appropriate amount of hydrochloric acid hydrochloric acid reference substance, accurately weigh it, and add the mobile phase to make a solution containing 0.1 mg per 1 ml. Preparation of test solution Take about 0.1g of the powder of this product (passed through No. 3 sieve), weigh accurately, place in a 100ml volumetric flask, add 80ml of mobile phase, ultrasonically treat (power 250W, frequency 40kHz) for 40 minutes, cool, dilute to scale with mobile phase, shake well, filter, and take the filtrate. Determination method Accurately aspirate 5R of the reference solution and 5~20 hours of the test solution respectively and inject them into the liquid chromatograph for determination. This product is calculated on the basis of dry product, and the content of phellodendron alkaloid in terms of phellodendron alkaloid hydrochloride (C20H17NO4 • HC1) shall not be less than 30%.
Phellodendron alkaloid is determined according to high performance liquid chromatography (General Rule 0512).
Chromatographic conditions and system suitability test Octadecylsilane bonded silica gel was used as filler; acetonitrile-0.1% phosphoric acid solution (0.2g of sodium dodecylsulfonate was added per 100ml) (36:64) was used as mobile phase; the detection wavelength was 284nm. The number of theoretical plates calculated based on the hydrochloride phellodendron peak should not be less than 6000.
Preparation of reference solution Take an appropriate amount of hydrochloride phellodendron reference, accurately weigh it, add mobile phase to make a solution containing 0.1mg per 1ml, and obtain it.
Preparation of test solution Take about 0.5g of the powder of this product (passed through a No. 4 sieve), accurately weigh it, place it in a stoppered conical flask, accurately add 25ml of mobile phase, weigh it, ultrasonically treat it (power 250W, frequency 40kHz) for 30 minutes, let it cool, weigh it again, make up the lost weight with mobile phase, shake it well, filter it, and take the filtrate to obtain it. Determination method: Accurately pipette 5 ml of reference solution and test solution respectively, inject into liquid chromatograph, and determine.
This product contains phellodendron hydrochloride (HC1) calculated as dry product, which shall not be less than 0.34%.
Decoction piece
Phellodendron removes impurities, sprays with water, moistens thoroughly, cuts into strips, and dries.
This product is in the form of silk strips. The outer surface is yellow-brown or yellow-brown. The inner surface is dark yellow or light brown with longitudinal ridges. The cut surface is fibrous, flaky and layered, dark yellow. It tastes very bitter.
Same as medicinal material.
Salted phellodendron Take phellodendron silk and fry it dry according to the salt water roasting method (General Rule 0213).
This product is shaped like phellodendron silk, with a dark yellow surface and occasional burnt spots. It tastes very bitter and slightly salty.
Same as medicinal material. Huangbai charcoal Take Huangbai silk and stir-fry it according to the charcoal method (General Rule 0213) until the surface is burnt black.
This product is shaped like Huangbai silk, with a burnt black surface and dark brown or brown-black inside. It is light, brittle and easy to break. It tastes bitter and astringent.
Bitter, cold. It enters the kidney and bladder meridians.
Clears heat and dries dampness, purges fire and removes steaming, detoxifies and treats sores. It is used for damp-heat diarrhea, jaundice and red urine, vaginal itching, hot stranguria and pain, beriberi, bone steaming and fatigue fever, night sweats, spermatorrhea, sores, swelling and poison, eczema and wet sores. Salt Huangbai nourishes yin and reduces fire. It is used for yin deficiency and excessive fire, night sweats and bone steaming.
Appropriate amount for external use for 3~12g.
Place in a ventilated and dry place, moisture-proof.
Raw Material Selection
Quality Inspection
Processing
Packaging
Quality Control
Storage and Transportation
Raw Material Selection
Chinese Herbal Medicine Cultivation: We strictly select Chinese herbal medicine cultivation bases from authentic medicinal material production areas to ensure the high quality of Chinese medicinal materials.
Herbal Medicine Procurement: We procure high-quality Chinese herbs from around the world to ensure that the herbs are pure, natural, and pollution-free.
Quality Inspection
Raw Material Testing: All purchased Chinese herbs must undergo strict quality inspection before entering the warehouse, including sensory indicators such as appearance, smell, and color, as well as physical and chemical indicators such as component analysis, heavy metal detection, and pesticide residue testing.
Processing
Cleaning: Thoroughly clean the Chinese herbs using clean water sources to remove dirt, impurities, and microorganisms.
Cutting: Based on the characteristics of different Chinese herbs, we adopt appropriate cutting processes, including slicing, segmenting, and shredding, to ensure the efficacy of the herbs and ease of use.
Drying: Use traditional sun-drying and modern drying techniques to ensure that the moisture content of Chinese herbs meets national standards, maintaining the efficacy and storage life of the herbs.
Selection
Screening: Carefully select the Chinese herbs to remove impurities, fragments, and non-conforming items, ensuring the purity and high quality of the herbs.
Sorting: Sort the herbs according to their specifications and grades to ensure product consistency and standardization.
Packaging
Packaging Handling: In a clean packaging workshop, use modern packaging equipment to package the Chinese herbs, ensuring the sealing and hygiene of the packaging and extending the product's shelf life.
Label Identification: Each package is labeled with detailed information, including the name of the herb, specification, place of origin, production date, etc., ensuring the traceability of the product.
Quality Control
Process Monitoring: Strict quality monitoring is carried out at every stage of production to ensure that the products meet national standards and customer requirements.
Final Inspection: Every batch of products undergoes final quality inspection before leaving the factory, including appearance, composition, and microbial indicators, ensuring the safety and efficacy of the products.
Storage and Transportation
Storage: Store the products in warehouses that comply with GSP standards to ensure product quality and stability. Warehouse environment control includes temperature, humidity, and ventilation, ensuring that the herbs do not get damp or deteriorate.
Transportation: Use professional logistics transportation methods to ensure the safety and integrity of the products during transportation, delivering them to customers on time. We cooperate with multiple international logistics companies to ensure fast and efficient global delivery.
Raw Material Selection
Chinese Herbal Medicine Cultivation: We strictly select Chinese herbal medicine cultivation bases from authentic medicinal material production areas to ensure the high quality of Chinese medicinal materials.
Herbal Medicine Procurement: We procure high-quality Chinese herbs from around the world to ensure that the herbs are pure, natural, and pollution-free.
Quality Inspection
Raw Material Testing: All purchased Chinese herbs must undergo strict quality inspection before entering the warehouse, including sensory indicators such as appearance, smell, and color, as well as physical and chemical indicators such as component analysis, heavy metal detection, and pesticide residue testing.
Processing
Cleaning: Thoroughly clean the Chinese herbs using clean water sources to remove dirt, impurities, and microorganisms.
Cutting: Based on the characteristics of different Chinese herbs, we adopt appropriate cutting processes, including slicing, segmenting, and shredding, to ensure the efficacy of the herbs and ease of use.
Drying: Use traditional sun-drying and modern drying techniques to ensure that the moisture content of Chinese herbs meets national standards, maintaining the efficacy and storage life of the herbs.
Selection
Screening: Carefully select the Chinese herbs to remove impurities, fragments, and non-conforming items, ensuring the purity and high quality of the herbs.
Sorting: Sort the herbs according to their specifications and grades to ensure product consistency and standardization.
Packaging
Packaging Handling: In a clean packaging workshop, use modern packaging equipment to package the Chinese herbs, ensuring the sealing and hygiene of the packaging and extending the product's shelf life.
Label Identification: Each package is labeled with detailed information, including the name of the herb, specification, place of origin, production date, etc., ensuring the traceability of the product.
Quality Control
Process Monitoring: Strict quality monitoring is carried out at every stage of production to ensure that the products meet national standards and customer requirements.
Final Inspection: Every batch of products undergoes final quality inspection before leaving the factory, including appearance, composition, and microbial indicators, ensuring the safety and efficacy of the products.
Storage and Transportation
Storage: Store the products in warehouses that comply with GSP standards to ensure product quality and stability. Warehouse environment control includes temperature, humidity, and ventilation, ensuring that the herbs do not get damp or deteriorate.
Transportation: Use professional logistics transportation methods to ensure the safety and integrity of the products during transportation, delivering them to customers on time. We cooperate with multiple international logistics companies to ensure fast and efficient global delivery.
Processing
Cleaning: Thoroughly clean the Chinese herbs using clean water sources to remove dirt, impurities, and microorganisms.
Cutting: Based on the characteristics of different Chinese herbs, we adopt appropriate cutting processes, including slicing, segmenting, and shredding, to ensure the efficacy of the herbs and ease of use.
Drying: Use traditional sun-drying and modern drying techniques to ensure that the moisture content of Chinese herbs meets national standards, maintaining the efficacy and storage life of the herbs.
Selection
Screening: Carefully select the Chinese herbs to remove impurities, fragments, and non-conforming items, ensuring the purity and high quality of the herbs.
Sorting: Sort the herbs according to their specifications and grades to ensure product consistency and standardization.
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