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Notopterygium wilfordii

This product is the dried rhizome and root of Notopterygium incisum Ting exH. T. Chang or Notopterygium franchetii H. de Boiss. of the Umbelliferae family. It is dug up in spring and autumn, the fibrous roots and mud are removed, and it is dried in the sun.

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  • 【Properties】

Notopterygium wilfordii is a cylindrical, slightly curved rhizome, 4 to 13 cm long, 0.6 to 2.5 cm in diameter, with a stem scar at the top. The surface is brown to dark brown, and the outer skin is yellow where it falls off. The internodes are shortened, forming a tightly raised ring, resembling a silkworm, commonly known as "silkworm qiang"; the internodes are elongated, shaped like bamboo nodes, commonly known as "bamboo node qiang". There are many dot-like or tumor-like protruding root scars and brown broken scales on the nodes. It is light, brittle, easy to break, and has an uneven cross section with many cracks. The cortex is yellow-brown to dark brown, oily, with brown oil spots, the wood is yellow-white, the rays are obvious, and the pith is yellow to yellow-brown. It has a fragrant smell and tastes slightly bitter and spicy.Long-leaved Notopterygium wilfordii is a rhizome and root. The rhizome is cylindrical, with the remains of stems and leaf sheaths at the top, and the root is conical, with longitudinal wrinkles and lenticels; the surface is brown, with dense rings near the rhizome, 8 to 15 cm long, 1 to 3 cm in diameter, commonly known as "tiaoqiang". Some rhizomes are thick, irregularly nodular, with several stem bases at the top, and thin roots, commonly known as "big-headed qiang". The texture is brittle, easy to break, the cross section is slightly flat, the bark is light brown, and the wood is yellow-white. The smell is light.

  • 【Identification】

Take 1g of the powder of this product, add 5ml of methanol, ultrasonically treat for 20 minutes, let it stand, and take the supernatant as the test solution. Take another purple flower peucedanum reference substance, add methanol to make a solution containing 0.5mg per 1ml as the reference solution. According to the thin layer chromatography method (General Rule 0502), 2 to 4 μl of each of the above two solutions are taken and spotted on the same silica gel G thin layer plate prepared with 3% sodium acetate solution, and chloroform-methanol (8:2) is used as the developing agent. Develop, take out, dry, and inspect under ultraviolet light (365nm). In the chromatogram of the test sample, the same blue fluorescent spot appears at the corresponding position of the chromatogram of the reference sample.

  • 【Inspection】

The total ash content shall not exceed 8.0% (General Rule 2302).
Acid insoluble ash shall not exceed 3 0% (General Rule 2302).

  • 【Characteristic spectrum】

Determine according to the high performance liquid chromatography method (General Rule 0512).
Chromatographic conditions and system suitability test Octadecylsilane bonded silica gel (non-hydrophilic) was used as the filler (column length was 250 mm, inner diameter was 4.6 mm, and particle size was 5 pm); acetonitrile was used as mobile phase A, and 0.1% phosphoric acid solution was used as mobile phase B, and gradient elution was performed according to the provisions in the following table; column temperature was 25°C; detection wavelength was 246 nm. The number of theoretical plates calculated based on the notopterygium alcohol peak should not be less than 18,000.

Time (minutes) Mobile phase A (%) Mobile phase B (%)
0~6
48→53 52→47
6~12 53 47
12~20 53→80 47→20
20~30 80 20
Preparation of control extract solution Take 10 mg of notopterygium control extract, accurately weigh it, place it in a 5 ml volumetric flask, add methanol to dissolve and dilute to the scale, shake well, and obtain.
Preparation of test solution Take the test solution under [Content determination] to obtain.
Determination method Accurately aspirate 10μ1 of the reference extract solution and the test solution, inject into the liquid chromatograph, determine, and record the chromatogram to obtain.
The characteristic spectrum of the test product should show chromatographic peaks corresponding to the retention time of the four main characteristic peaks in the reference extract.
 
Comparison of characteristic spectra
Peak 1: Notopterygium wilfordii alcohol Peak 2: Phenethyl ferulate Peak 3: Isoimperatorin Peak 4: Falcarya diol
  • 【Extract】

Determined by hot soaking method under the method for determination of alcohol-soluble extract (General Rule 2201), using ethanol as solvent, the content shall not be less than 15.0%.

  • 【Content Determination】

Volatile oil shall be determined according to the method for determination of volatile oil (General Rule 2204).

This product shall contain not less than 1.4% (ml/g) volatile oil. Qianghuo alcohol and isoimperatorin were determined according to the high performance liquid chromatography method (General Rule 0512).
Chromatographic conditions and system suitability test Octadecylsilane bonded silica gel was used as filler; acetonitrile-water (44:56) was used as mobile phase; the detection wavelength was 310nm.
The theoretical plate number calculated based on the Qianghuo alcohol peak should not be less than 5000. Preparation of reference solution Take appropriate amount of Qianghuo alcohol reference substance and isoimperatorin reference substance, accurately weigh them, add methanol to make a mixed solution containing 60μg of Qianghuo alcohol and 30μg of isoimperatorin per 1ml, and obtain it.
Preparation of test solution Take about 0.4g of the powder of this product (passed through No. 3 sieve), accurately weigh it, put it in a stoppered conical flask, accurately add 50ml of methanol, weigh it, ultrasonically treat it (power 250W, frequency 50kHz) for 30 minutes, let it cool, weigh it again, make up the lost weight with methanol, shake it well, filter it, and take the filtrate to obtain it. Determination method Accurately pipette 5μ1 of the reference solution and 5~10μ1 of the test solution, inject into the liquid chromatograph, and measure. The total amount of qianghuo alcohol (C21H22O5) and isoimperatorin (C16 H14O4) in this product, calculated on the basis of dry product, shall not be less than 0.40%.

Decoction pieces

  • 【Processing】

Remove impurities, wash, moisten thoroughly, cut into thick slices, and dry.

  • 【Properties】

This product is in the form of circular, irregular cross-section or oblique slices, with brown to dark brown epidermis, brown outer surface of the cut surface, yellow-white wood, and some with visible radial textures. It is light and crisp. It has a fragrant smell and tastes slightly bitter and pungent.

  • 【Inspection】

The moisture content shall not exceed 9.0% (General Rule 0832 Method 4).

  • 【Identification】【Inspection】 (Total ash content Acid insoluble ash) 【Characteristic spectrum】

【Extract】 【Content determination】

Same as medicinal material.

  • 【Nature and flavor and meridians】

Spicy, bitter, warm. Enters bladder and kidney meridians.

  • 【Functions and indications】

Relieves cold, dispels wind and dampness, relieves pain. Used for colds, headaches, stiff neck, rheumatic pain, shoulder and back pain.

  • 【Usage and dosage】

3~10g.

  • 【Storage】

Store in a cool and dry place to prevent moth.

Production Process

Raw Material Selection

Quality Inspection

Processing

Packaging

Quality Control

Storage and Transportation

Raw Material Selection

Chinese Herbal Medicine Cultivation: We strictly select Chinese herbal medicine cultivation bases from authentic medicinal material production areas to ensure the high quality of Chinese medicinal materials.

Herbal Medicine Procurement: We procure high-quality Chinese herbs from around the world to ensure that the herbs are pure, natural, and pollution-free.

Quality Inspection

Raw Material Testing: All purchased Chinese herbs must undergo strict quality inspection before entering the warehouse, including sensory indicators such as appearance, smell, and color, as well as physical and chemical indicators such as component analysis, heavy metal detection, and pesticide residue testing.

Processing

Cleaning: Thoroughly clean the Chinese herbs using clean water sources to remove dirt, impurities, and microorganisms.

Cutting: Based on the characteristics of different Chinese herbs, we adopt appropriate cutting processes, including slicing, segmenting, and shredding, to ensure the efficacy of the herbs and ease of use.

Drying: Use traditional sun-drying and modern drying techniques to ensure that the moisture content of Chinese herbs meets national standards, maintaining the efficacy and storage life of the herbs.

Selection

Screening: Carefully select the Chinese herbs to remove impurities, fragments, and non-conforming items, ensuring the purity and high quality of the herbs.

Sorting: Sort the herbs according to their specifications and grades to ensure product consistency and standardization.

Packaging

Packaging Handling: In a clean packaging workshop, use modern packaging equipment to package the Chinese herbs, ensuring the sealing and hygiene of the packaging and extending the product's shelf life.

Label Identification: Each package is labeled with detailed information, including the name of the herb, specification, place of origin, production date, etc., ensuring the traceability of the product.

Quality Control

Process Monitoring: Strict quality monitoring is carried out at every stage of production to ensure that the products meet national standards and customer requirements.

Final Inspection: Every batch of products undergoes final quality inspection before leaving the factory, including appearance, composition, and microbial indicators, ensuring the safety and efficacy of the products.

Storage and Transportation

Storage: Store the products in warehouses that comply with GSP standards to ensure product quality and stability. Warehouse environment control includes temperature, humidity, and ventilation, ensuring that the herbs do not get damp or deteriorate.

Transportation: Use professional logistics transportation methods to ensure the safety and integrity of the products during transportation, delivering them to customers on time. We cooperate with multiple international logistics companies to ensure fast and efficient global delivery.

Raw Material Selection

Chinese Herbal Medicine Cultivation: We strictly select Chinese herbal medicine cultivation bases from authentic medicinal material production areas to ensure the high quality of Chinese medicinal materials.

Herbal Medicine Procurement: We procure high-quality Chinese herbs from around the world to ensure that the herbs are pure, natural, and pollution-free.

Quality Inspection

Raw Material Testing: All purchased Chinese herbs must undergo strict quality inspection before entering the warehouse, including sensory indicators such as appearance, smell, and color, as well as physical and chemical indicators such as component analysis, heavy metal detection, and pesticide residue testing.

Processing

Cleaning: Thoroughly clean the Chinese herbs using clean water sources to remove dirt, impurities, and microorganisms.

Cutting: Based on the characteristics of different Chinese herbs, we adopt appropriate cutting processes, including slicing, segmenting, and shredding, to ensure the efficacy of the herbs and ease of use.

Drying: Use traditional sun-drying and modern drying techniques to ensure that the moisture content of Chinese herbs meets national standards, maintaining the efficacy and storage life of the herbs.

Selection

Screening: Carefully select the Chinese herbs to remove impurities, fragments, and non-conforming items, ensuring the purity and high quality of the herbs.

Sorting: Sort the herbs according to their specifications and grades to ensure product consistency and standardization.

Packaging

Packaging Handling: In a clean packaging workshop, use modern packaging equipment to package the Chinese herbs, ensuring the sealing and hygiene of the packaging and extending the product's shelf life.

Label Identification: Each package is labeled with detailed information, including the name of the herb, specification, place of origin, production date, etc., ensuring the traceability of the product.

Quality Control

Process Monitoring: Strict quality monitoring is carried out at every stage of production to ensure that the products meet national standards and customer requirements.

Final Inspection: Every batch of products undergoes final quality inspection before leaving the factory, including appearance, composition, and microbial indicators, ensuring the safety and efficacy of the products.

Storage and Transportation

Storage: Store the products in warehouses that comply with GSP standards to ensure product quality and stability. Warehouse environment control includes temperature, humidity, and ventilation, ensuring that the herbs do not get damp or deteriorate.

Transportation: Use professional logistics transportation methods to ensure the safety and integrity of the products during transportation, delivering them to customers on time. We cooperate with multiple international logistics companies to ensure fast and efficient global delivery.

Processing

Cleaning: Thoroughly clean the Chinese herbs using clean water sources to remove dirt, impurities, and microorganisms.

Cutting: Based on the characteristics of different Chinese herbs, we adopt appropriate cutting processes, including slicing, segmenting, and shredding, to ensure the efficacy of the herbs and ease of use.

Drying: Use traditional sun-drying and modern drying techniques to ensure that the moisture content of Chinese herbs meets national standards, maintaining the efficacy and storage life of the herbs.

Selection

Screening: Carefully select the Chinese herbs to remove impurities, fragments, and non-conforming items, ensuring the purity and high quality of the herbs.

Sorting: Sort the herbs according to their specifications and grades to ensure product consistency and standardization.

After-Sales Service

Quality Assurance

All Chinese herbal products come with a one-year quality guarantee. If any quality issues are found within the warranty period, the company will provide replacement or refund services free of charge.

Quality Assurance

Product Warranty:All Chinese herbal products come with a one-year quality guarantee. If any quality issues are found within the warranty period, the company will provide replacement or refund services free of charge.

Quality Complaint Handling:Customers can submit quality complaints via phone, email, or online customer service, and the company will respond and resolve the issue within 24 hours.

Customer Consultation Service

The company offers 24-hour round-the-clock customer support. Customers can consult about product-related issues at any time via phone, email, or online customer service.

Customer Consultation Service

24/7 Customer Support:The company offers 24-hour round-the-clock customer support. Customers can consult about product-related issues at any time via phone, email, or online customer service.

Professional Consultation:The company has a team of professional Chinese medicine pharmacists who provide expert consultation on the use, health benefits, and efficacy of Chinese medicines.

Logistics Tracking Service

After placing an order, customers can check the order status through the company's website or customer service system to monitor logistics information in real-time.

Logistics Tracking Service

Order Tracking:After placing an order, customers can check the order status through the company's website or customer service system to monitor logistics information in real-time.

Delay Notifications:If there are any delays during the logistics process, the company will notify customers immediately and provide solutions.

User Training and Guidance

Each product comes with a detailed user manual to guide customers in the proper use of Chinese medicines.

User Training and Guidance

User Manuals:Each product comes with a detailed user manual to guide customers in the proper use of Chinese medicines.

Online Training:The company regularly holds online training courses to explain the usage methods, contraindications, and health benefits of Chinese medicines, helping customers use the products better.

Customer Feedback and Improvement

The company regularly sends satisfaction surveys to customers to collect their opinions and suggestions.

Customer Feedback and Improvement

Satisfaction Surveys:The company regularly sends satisfaction surveys to customers to collect their opinions and suggestions.

Continuous Improvement:Based on customer feedback, the company continuously improves its products and services to ensure customer satisfaction.

Global Customer Service

The company provides multilingual customer service to ensure smooth communication with overseas customers.

Global Customer Service

Multilingual Support:The company provides multilingual customer service to ensure smooth communication with overseas customers.

Localized Service:Setting up local service centers in major markets to provide faster after-sales support and service response.

Workshop Display

【 Sun Drying 】

【 Packaging Products 】

【 Processing Center 】

【 Testing Center 】